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KMID : 0606920080160020113
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Biomolecules & Therapeutics
2008 Volume.16 No. 2 p.113 ~ p.117
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Involvement of pCREB Expression in Inhibitory Effects of Coptis japonica on Morphine-induced Psychological Dependence
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Kwon Seung-Hwan
Jang Choon-Gon
Lee Seok-Yong
Ha Ri-Ra
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Abstract
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Morphine is a potent analgesic with significant abuse potential, because of drug craving and psychological dependence. It is reported that repeated treatment of morphine can produce conditioned place preference (CPP) showing a reinforcing effect in mice. Previously, we have reported the inhibitory effect of the methanolic extract of Coptis japonica (MCJ) on morphine-induced CPP in mice. The present study was employed whether p-CREB expression is involved in the inhibitory effect of MCJ on the morphine-induced CPP in the mouse hippocampus. Repeated administration of MCJ 100 mg/kg inhibited morphine-induced CPP. Expression of p-CREB was increased in the dentate gyrus of the hippocampus that had undergone morphineinduced CPP. This increase of expression was significantly inhibited by administration of MCJ 100 mg/kg, compared to the morphine control group. Taken together, these results suggest that MCJ inhibits morphine-induced CPP through the regulation of p-CREB expression in the mouse dentate gyrus of the hippocampus.
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KEYWORD
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Conditioned place preference, Coptis japonica, p-CREB, Immunohistochemistry
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